منابع مشابه
Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor.
Mechanosensitive ion channels are thought to mediate stretch-induced contraction in vascular smooth muscle cells (VSMCs); however, the molecular identity of the mechanosensitive ion channel complex is unknown. Although recent reports suggest degenerin/epithelial Na+ channel (DEG/ENaC) proteins may be mechanosensors in sensory neurons, their role as mechanosensors in vascular tissue has not been...
متن کاملMolecular determinants of desensitization in an ENaC/degenerin channel.
Epithelial Na(+) channel (ENaC)/degenerin family members are involved in mechanosensation, blood pressure control, pain sensation, and the expression of fear. Several of these channel types display a form of desensitization that allows the channel to limit Na(+) influx during prolonged stimulation. We used site-directed mutagenesis and chemical modification, functional analysis, and molecular d...
متن کاملThe Genetic Architecture of Degenerin/Epithelial Sodium Channels in Drosophila
Degenerin/epithelial sodium channels (DEG/ENaC) represent a large family of animal-specific membrane proteins. Although the physiological functions of most family members are not known, some have been shown to act as nonvoltage gated, amiloride-sensitive sodium channels. The DEG/ENaC family is exceptionally large in genomes of Drosophila species relative to vertebrates and other insects. To elu...
متن کاملBiochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels.
Personal experience informs us that receptors in the skin transmit a wealth of tactile information. We can detect the caress of a cheek, the texture of fabric, a fly alighting on our hand, and a pinch of our arm. Yet of all the vertebrate senses, touch is the least understood at the molecular level. For many years it has been postulated that the core components of mechanosensors are ion channel...
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Advanced perceptual systems are faced with the problem of securing a principled relationship between the world and its internal representation. I propose a uniied approach to visual representation, based on Shepard's (1968) notion of second-order isomorphism. According to the proposed theory, a shape is represented internally by the responses of a few tuned modules, each of which is broadly sel...
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ژورنال
عنوان ژورنال: Nature
سال: 1993
ISSN: 0028-0836,1476-4687
DOI: 10.1038/361504a0